Current guidelines for diagnosis and treatment of allergic rhinoconjunctivitis and urticaria recommend nonsedating antihistamines as first line treatment [1, 2].WARNING RISK OF RESPIRATORY DEPRESSION, MEDICATION ERRORS, ABUSE POTENTIAL Fatal respiratory depression has occurred in patients treated with ACTIQ, including following use in opioid non-tolerant patients and improper dosing.It is usual to classify H1-antihistamines into two classes: old ones, called first-generation agents, which are sedating and recent ones, called second-generation agents which have slight or no sedating effects because they do not cross the blood-brain barrier.
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Less common adverse effects include palpitations, urinary retention, bloating, constipation, headache, and confusion.
Scopolamine, which is most commonly prescribed as a transdermal patch, should be administered at least 30 minutes prior to exposure to motion stimuli.
Other H1-antihistamines having an important antimuscarinic activity like diphenhydramine and dimenhydrinate, are used in preventive and curative treatment of motion sickness, but scopolamine which has no antihistamine effect seems more effective than them in preventive treatment.
Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine.
Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms.